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Theophylline is indicated for the treatment of the symptoms and reversible airflow obstruction associated with chronic asthma and other chronic lung diseasese.gemphysema and chronic bronchitis.

Most serum theophylline assays in clinical use are immunoassays which are specific for theophyllineOther xanthines such as caffeinedyphyllineand pentoxifylline are not detected by these assaysSome drugse.gcefazolincephalothinhowevermay interfere with certain HPLC techniquesCaffeine and xanthine metabolites in neonates or patients with renal dysfunction may cause the reading from some dry reagent office methods to be higher than the actual serum theophylline concentration.

Clearance represents the volume of blood completely cleared of theophylline by the liver in one minuteValues listed were generally determined at serum theophylline concentrations 3 months of ageIn contrastthe large fraction of the theophylline dose excreted in the urine as unchanged theophylline and caffeine in neonates requires careful attention to dose reduction and frequent monitoring of serum theophylline concentrations in neonates with reduced renal functionSee WARNINGS

While simultaneously instituting treatmentcontact a regional poison center to obtain updated information and advice on individualizing the recommendations that follow.

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