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Hydroxyurea may be used as part of a combination therapyThis means you may need to take it with other medications.

To decrease the risk of contactadvise caregivers to wear disposable gloves when handling HYDREA or bottles containing HYDREAWash hands with soap and water before and after contact with the bottle or capsules when handling HYDREADo not open HYDREA capsulesAvoid exposure to crushed or opened capsulesIf contact with crushed or opened capsules occurs on the skinwash affected area immediately and thoroughly with soap and waterIf contact with crushed or opened capsules occurs on the eye(sthe affected area should be flushed thoroughly with water or isotonic eyewash designated for that purpose for at least 15 minutesIf the powder from the capsule is spilledimmediately wipe it up with a damp disposable towel and discard in a closed containersuch as a plastic bagas should the empty capsulesThe spill areas should then be cleaned three times using a detergent solution followed by clean waterKeep the medication away from children and petsContact your doctor for instructions on how to dispose of outdated capsules.

Cutaneous vasculitic toxicitiesincluding vasculitic ulcerations and gangrenehave occurred in patients with myeloproliferative disorders during therapy with hydroxyureaThese vasculitic toxicities were reported most often in patients with a history ofor currently receivinginterferon therapyIf cutaneous vasculitic ulcers occurinstitute treatment and discontinue HYDREA.

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