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For information about contraindications of antibacterial agents clarithromycin and amoxicillin indicated in combination with nexium, refer to the contraindications section of their package inserts.

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Cutaneous lupus erythematosusCLEand systemic lupus erythematosusSLEhave been reported in patients taking PPIsincluding esomeprazoleThese events have occurred as both new onset and an exacerbation of existing autoimmune diseaseThe majority of PPI-induced lupus erythematosus cases were CLE.

Triple TherapyNEXIUM plus amoxicillin and clarithromycinNEXIUMin combination with amoxicillin and clarithromycinis indicated for the treatment of patients with Hpylori infection and duodenal ulcer diseaseactive or history of within the past 5 yearsto eradicate HpyloriEradication of Hpylori has been shown to reduce the risk of duodenal ulcer recurrencesee DOSAGE AND ADMINISTRATION and Clinical Studies

Esomeprazole is the S-isomer of omeprazoleFour epidemiological studies compared the frequency of congenital abnormalities among infants born to women who used omeprazole during pregnancy with the frequency of abnormalities among infants of women exposed to H2-receptor antagonists or other controls.

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