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The effect of hepatic impairment on the pharmacokinetics of PREMARIN Vaginal Cream has not been studied.

Other binding proteins may be elevated in serumi.ecorticosteroid binding globulinCBGsex hormone-binding globulinSHBGleading to increased circulating corticosteroid and sex steroidsrespectivelyFree or biologically active hormone concentrations may be decreased.

The use of estrogen-alone and estrogen plus progestin therapy has been reported to result in an increase in abnormal mammogramsrequiring further evaluation.

Increased plasma high-density lipoproteinHDLand HDL 2 cholesterol subfraction concentrationsreduced low-density lipoproteinLDLcholesterol concentrationsincreased triglyceride levels.

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