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Labetalol HCl produces dose-related falls in blood pressure without reflex tachycardia and without significant reduction in heart ratepresumably through a mixture of its alphaand beta-blocking effectsHemodynamic effects are variablewith smallnonsignificant changes in cardiac output seen in some studies but not othersand small decreases in total peripheral resistanceElevated plasma renins are reduced.
Xatral SR Prolonged release tabletsConsumer Medicines Information leaflets of prescription and over-the-counter medicines.
HOW TO USESee also Warning section.Take this medication by mouthusually twice a day or as directed by your doctorYou may take this medication with or without foodbut it is important to choose one way and take this medication the same way with every dose.Dosage is based on your medical condition and response to treatmentTo reduce your risk of side effectsyour doctor may direct you to start this medication at a low dose and gradually increase your doseFollow your doctor’s instructions carefully.Use this medication regularly to get the most benefit from itTo help you remembertake it at the same times each day.For the treatment of high blood pressureit may take several weeks before you get the full benefit of this drugIt is important to continue taking this medication even if you feel wellMost people with high blood pressure do not feel sick.Tell your doctor if your condition does not improve or if it worsensfor exampleyour blood pressure readings remain high or increase
Although beta-adrenergic receptor blockade is useful in the treatment of angina and hypertensionthere are also situations in which sympathetic stimulation is vitalFor examplein patients with severely damaged heartsadequate ventricular function may depend on sympathetic driveBeta-adrenergic blockade may worsen A-V block by preventing the necessary facilitating effects of sympathetic activity on conductionBeta 2adrenergic blockade results in passive bronchial constriction by interfering with endogenous adrenergic bronchodilator activity in patients subject to bronchospasmand it may also interfere with exogenous bronchodilators in such patients.
To lower your risk of dizziness and lightheadednessget up slowly when rising from a sitting or lying position.
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labetalol normodyne, trandate usual maintenance doses are 200 -400 mg twice side effects may be less if labetalol is given in three daily doses rather labetalol oral route side effects mayo clinic side effects.