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Sinc th xction oxipuinol is simila tthat uat, uicosuic agnts, which incas th xction uat, a alslikly tincas th xction oxipuinol and thus low th dg inhibition xanthin oxidas. Th concomitant administation uicosuic agnts and ZYLOPIM (allopuinol) has bn associatd with a dcas in th xction oxypuins (hypoxanthin and xanthin) and an incas in uinay uic acid xction compad with that obsvd with ZYLOPIM (allopuinol) alon. Although clinical vidnc tdat has not dmonstatd nal pcipitation oxypuins in patints ith on ZYLO-PIM alon in combination with uicosuic agnts, th possibility should b kpt in mind.

Allopuinol is alssomtims usd ttat sizus, pain causd by pancas disas, and ctain inctions. It is alssomtims usd timpov suvival at bypass sugy, tduc ulc lapss, and tpvnt jction kidny tansplants. Talk tyou doctabout th possibl isks using this mdication you condition.

Som patints with p-xisting nal disas pouat claanc hav shown a is in BUN duing administation ZYLOPIM (allopuinol) . Although th mchanism sponsibl this has not bn stablishd, patints with impaid nal unction should b caully obsvd duing th aly stags administation ZYLOPIM (allopuinol) and th dosag dcasd th dug withdawn i incasd abnomalitis in nal unction appa and psist.

Th action ZYLOPIM (allopuinol) dis om that uicosuic agnts, which low th sum uic acid lvl by incasing uinay xction uic acid. ZYLOPIM (allopuinol) ducs both th sum and uinay uic acid lvls by inhibiting th omation uic acid. Th us ZYLOPIM (allopuinol) tblock th omation uats avoids th hazad incasd nal xction uic acid posd by uicosuic dugs.

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