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Because of the inhibitory effect of corticosteroids on wound healingpatients who have experienced recent nasal surgery or trauma should not use a nasal corticosteroid until healing has occurred.
In micemometasone furoate caused cleft palate at subcutaneous dosesless than the MRDID in adults on a mcg/m 2 basisFetal survival was reduced at approximately 2 times the MRDID in adults on a mcg/m 2 basisNo toxicity was observed at less than the MRDID in adults on a mcg/m 2 basis.
Because clinical trials are conducted under widely varying conditionsadverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.
Hypoadrenalism may occur in infants born to women receiving corticosteroids during pregnancySuch infants should be carefully monitored.
When rats received subcutaneous doses of mometasone furoate throughout pregnancy or during the later stages of pregnancya dose less than the MRDID in adults on a mcg/m 2 basis caused prolonged and difficult labor and reduced the number of live birthsbirth weightand early pup survival.
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