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Paroxetine, a potent inhibitor of cyp2d6, may lead to reduced concentrations of endoxifen, one of the most important active metabolites of tamoxifen.

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Cyclic regimenInitial dose12.5 mg orally once a daystarting 14 days prior to the anticipated start of menstruation through to the first full day of mensesand repeated with each new cycle Maintenance dose12.5 to 25 mg orally once a day.

Paroxetine may also be used for purposes not listed in this medication guide.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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Paroxetine is known as a selective serotonin reuptake inhibitorSSRIThis medication may improve your moodsleepappetiteand energy level and may help restore your interest in daily livingIt may decrease fearanxietyunwanted thoughtsand the number of panic attacksParoxetine may lessen premenstrual symptoms such as irritabilityincreased appetiteand depression.

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a double-blind study of paroxetine, fluoxetine, and placebo in outpatients with major depression – editor in this 8-week study, there was no difference in effectiveness between paroxetine, fluoxetine and placebo.