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CommentsPatients who are small or fragile may be started on 2.5 mg orally once a dayThe dosage should be adjusted according to patient responseIn generaltitration should proceed over 7 to 14 daysIf clinically warrantedtitration may proceed more rapidlyprovided the patient is assessed frequently.

Tell your doctor about all other heart or blood pressure medications you are taking.

The CHMPin the light of the data submitted and the scientific discussion within the Committeewas of the opinion that the SmPCslabelling and package leaflets should be harmonised across the EU.

Amlodipine is a calcium channel blockerIt blocks special channels on the surface of cells called calcium channelsthrough which calcium particles normally enterWhen calcium enter the cells in the muscles of blood vessel wallsthis causes contractionBy reducing the flow of calcium into the cellsamlodipine prevents the blood vessel walls from contractingthus lowering the blood pressure for patients with hypertension and helping to make it easier for patients with heart problems to pump blood around the body.

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