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If the patient is infected with VZVappropriate measures should be takenwhich may include antiviral therapy and supportive care.

Relatively oliguric patientsespecially those with tubular necrosis in the immediate postcadaveric transplant periodmay have delayed clearance of IMURAN or its metabolitesmay be particularly sensitive to this drugand are usually given lower doses.

Inhibition of the anticoagulant effect of warfarinwhen administered with azathioprinehas been reported.

All drugs may cause side effectsHowevermany people have no side effects or only have minor side effectsCall your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

The use of azathioprine for inhibition of renal homograft rejection is well establishedthe mechanism(sfor this action are somewhat obscureThe drug suppresses hypersensitivities of the cell-mediated type and causes variable alterations in antibody productionSuppression of T-cell effectsincluding ablation of T-cell suppressionis dependent on the temporal relationship to antigenic stimulus or engraftmentThis agent has little effect on established graft rejections or secondary responses.

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