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Use of danazol in pregnancy is contraindicated.

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There is epidemiological and toxicological evidence of hazard in human pregnancyDanazol is known to be associated with the risk of virilisation to the female foetus if administered during human pregnancyDanazol should not be used during pregnancyWomen of childbearing age should be advised to use an effectivenon-hormonalmethod of contraceptionIf the patient conceives during therapyDanazol should be stopped.

The possible causal relationship between danazol and many of the following events reportedly associated with its use remains to be defined.

Although it is unlikely that you will conceive while on danazolcare should be taken to avoid pregnancyIt is recommended that you use barrier contraceptioncondom or diaphragm or boththroughout treatment4

4Porphyriadanazol can induce ALA synthetase activity and hence porphyrin metabolism.

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