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Mebeverine violates the entrance of Naions into the cell by preventing the fast sodium channels myocyte cell membranealso it blocks the entering through the slow channels of ions Ca2hinders the process of depolarization of the cell membrane and prevents the reduction of muscle fibersMebeverine does not have an anticholinergic actionIt directly relaxes smooth musclemainly in the gastrointestinal tractThe preparation eliminates spasmwithout exerting a significant effect on the normal intestinal peristalsis.

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Colofac completely metabolizes in the human bodyThe first step of the metabolism is hydrolysis to form veratric acid and Mebeverine.

Down syndrome and Fragile X syndrome are the most common genetic causes of mental retardationProblems during pregnancy and birth Rubellainfection in pregnant mother Iodine deficiency in mothers Malnutrition is a common cause of reduced intelligence in children.

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