The antibiotic agents in chloramphenicol eye ointment are effective at killing strains of escherichia coli.
If a concomitant topical treatment to the eye is requiredthe administration of the different products should be separated by an adequate period of time.
This is not a list of all drugs or health problems that interact with chloramphenicol.
The following bacterial species are recognised conjunctival pathogens and may be susceptible to chloramphenicolHowever due to the prevalence of acquired resistance to chloramphenicol in these speciesthe results of susceptibility testing should be taken into account as soon as these are availableIf no susceptibility test result is availablethe choice of antibacterial agent should be influenced by local information on the likely prevalence of resistance to chloramphenicol in species that are commonly pathogenic in the eye.
Chloramphenicol may cause Gray syndrome and seriousfatal blood dyscrasiasGray syndrome occurs in pre-mature infants and neonatesIt involves abdominal distentionpallid cyanosisand vasomotor collapse leading to deathBlood dyscrasias are reductions in blood cells leading to aplastic anemiathrombocytopeniaand granulocytopenia.
Chloramphenicol exerts its antibacterial effect by binding to bacterial ribosomes and inhibiting bacterial protein synthesis at an early stage.
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the efficacy of chloramphenicol for the treatment of severe pneumonia ranges from 80 -84 , while that of ceftriaxone ranges from 85 to 97 .