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Corticosteroids are thought to actat least in partby controlling the rate of synthesis of proteinsAlthough there are a number of instances in which the synthesis of specific proteins is known to be induced by corticosteroidsthe links between the initial actions of the hormones and the final metabolic effects have not been completely elucidated.

Corticosteroids are contraindicated in patients with systemic fungal infections and in those with a history of possible or known hypersensitivity to these agents.

Other adverse reactions that may occur following the administration of a corticosteroid are necrotizing angiitisthrombophlebitisaggravation or masking of infectionsinsomniasyncopal episodesand anaphylactoid reactions.

BECAUSE OF ITS MARKED EFFECT ON SODIUM RETENTIONTHE USE OF FLUDROCORTISONE ACETATE IN THE TREATMENT OF CONDITIONS OTHER THAN THOSE INDICATED HEREIN IS NOT ADVISED

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