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Treatment resistance is defined as a lack of satisfactory clinical improvement despite the use of adequate doses of at least two different antipsychotic agentsincluding an atypical antipsychotic agentprescribed for adequate duration.

Older adults may be more sensitive to the side effects of this drugespecially constipationtrouble urinatingdrowsinessdizzinesslightheadednessand QT prolongationsee aboveDrowsinessdizzinessand lightheadedness can increase the risk of falling.

Clozaril can cause severe dizzinessslow heartbeatsfaintingor seizuresDo not take more of this medicine than recommended

Analysis of safety databases suggests that the use of Clozaril is associated with an increased risk of myocarditis especially duringbut not limited tothe first two months of treatmentSome cases of myocarditis have been fatalPericarditis/pericardial effusion and cardiomyopathy have also been reported in association with Clozaril usethese reports also include fatalitiesMyocarditis or cardiomyopathy should be suspected in patients who experience persistent tachycardia at restespecially in the first two months of treatmentand/or palpitationsarrhythmiaschest pain and other signs and symptoms of heart failuree.gunexplained fatiguedyspnoeatachypnoeaor symptoms that mimic myocardial infarctionOther symptoms which may be present in addition to the above include flu-like symptomsIf myocarditis or cardiomyopathy is suspectedClozaril treatment should be promptly stopped and the patient immediately referred to a cardiologist.

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clozaril may lower the ability of your body to fight infection.